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Symptoms of iron deficiency anemia often ease sooner, within a week or month. Other research suggests that intermittent iron supplementation (as opposed to daily) may bring the same benefits with fewer side effects. Higher amounts are usually spread across two daily doses for better absorption. Iron absorbs best on an empty stomach, but taking it this way can create digestive upset

They consider pros and cons, and substitutes

People often live with these symptoms for months before anyone connects them to B12

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The study noted repeated administration of methylene blue was the most effective for preservation of limb function.11 Though high quality randomized controlled trials are not yet available, methylene blue has also captured interest as a potential therapy for amelioration of post viral infection neurocognitive impairment and brain injury