It has been reported that the AUC 0- and C max of a single 2 mg oral dose of repaglinide were 105.9 ngh/mL and 60.3 ng/mL, respectively, for wild type ( *1/*1 ) CYP2C8, and 72.4 ngh/mL and 38.5 ng/mL for *3/*3 CYP2C8, respectively, and the plasma concentration decreased due to metabolic activation [17]
Lin H, Tsai Y, Liao P, Wei JC
In another study, a history of laparoscopy had an association with colonic ischemia with an odds ratio of 2.9 [11]
Patients should be counselled about these potential side effects before initiating treatment, and healthcare professionals should monitor for tolerability throughout the treatment course
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