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Mol Cell Endocrinol 351:152166 Strobel O, Dadabaeva N, Felix K, Hackert T, Giese NA, Jesenofsky R, Werner J (2016) Isolation and culture of primary human pancreatic stellate cells that reflect the context of their tissue of origin
Overview of 6 years therapy of type II diabetes: a progressive disease
To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH