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B12 is essential for the methylation reactions required to produce the lipids and proteins that constitute myelin
The following factors may increase the likelihood of having a B12 deficiency
Without a substantial change in UK medicines law or the development of a fully proven and licensed non-injectable alternative for malabsorption conditions like PA, the injection will remain a Prescription-Only Medicine
Mild pain or redness at injection site
Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function
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