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Areas where skin must constantly resist gravitational pull tend to show laxity earlier

Common mutations in p53, including missense, nonsense, and frameshift mutations, can increase the proteins half-life, leading to the accumulation of dysfunctional mutant p53 that impairs normal tumour-suppressive functions (37, 38)

Goal: Support tissue-healing and recovery processes based on preclinical evidence [1] [3]

Low levels of glutathione, especially in conditions of high oxidative stress, may lead to chronic disease and the loss of function associated with aging

While the genetic background of the individual with idiopathic vitiligo strongly influences the disease development preventing a successful recovery, the occupational vitiligo is generally induced by exposure and the return to the skin repigmentation is feasible, once the agent to which the subject is exposed to is removed from the work environment