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These results are not unprecedentedour lab has shown that some RNA viruses target host mRNAs encoding isoforms of thioredoxin reductase via RNA:RNA antisense interactions, which, like proteolysis, would likely also result in host selenoprotein knockdown, but by a different mechanism (22, 33)

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Figure 3: Acetaldehyde, a byproduct of alcohol, disrupts the balance of SAM and SAH, increasing homocysteine (Hcy) conversion to methionine while reducing cysteine and glutathione (GSH) production