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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

PubMed Vasireddi N, et al

But that barrier limits how much topically applied GHK-Cu actually reaches the follicles

We observed no significant changes in the expression of p53 or p21 in keloid lesions or fibroblasts compared to those in normal skin