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CYP1A1 metabolism of estrogen, polyaromatic hydrocarbons, and more CYP1A2 metabolism of caffeine, duloxetine, bupropion, aflatoxin B, and more CYP2A6 metabolism of nicotine, coumarin, and more CYP2B6 metabolism of ketamine, methadone, sertraline, and more CYP2C9 metabolism of warfarin, rosuvastatin, celecoxib, and more CYP2C19 metabolism of clopidogrel, some proton pump inhibitors, more CYP2D6 metabolism of some antidepressants, antipsychotics, more CYP3A4 metabolism of half of all prescription drugs CYP2E1 metabolism of fatty acids, alcohol, and some anesthetics Phase II detoxification genes: UGT, GST, Nrf2 Phase II detoxification involves taking the metabolites of phase I and modifying them to be easily excreted through conjugation with sulfur, glutathione, glucuronic acid, amino acids, or methyl groups

For upper arm injections, many GLP-1 devices recommend administration by another person due to the difficulty in reaching the correct area

Combination approaches are gaining popularity

doi: 10.1056/NEJMsr1809937 26 Amorim Moreira AlvesGTeranishiMTeixeira de Castro Gonalves OrtegaACJamesFPerera Molligoda ArachchigeAS

You will either stay on the same dose or your dose will increase to 1mg once a week if your blood sugar levels arent being managed well enough at 0.5mg