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25 The uncontrolled hyperglycemia resulting from such defects may lead to microvascular complications, including retinopathy, neuropathy, microangiopathy, and nephropathy, and macrovascular complications, such as coronary artery disease and peripheral vascular disease

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The use of GLP-1 RAs may be more effective in PD patients with insulin resistance or T2D, due to overlapping metabolic and neuroinflammatory pathways that may enhance therapeutic responsiveness