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Research consistently shows that with GLP-1 drugs, approximately 2540% of the total weight lost is lean mass, including muscle, rather than fat
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Head-to-Head Comparison Weight Loss Effectiveness: The Numbers When it comes to the numbers, retatrutide appears to have the edgeat least based on early trial data: Tirzepatide: Average weight loss of 21% over 72 weeks (about 15 months) Retatrutide: Average weight loss of 24.2% at 48 weeks, with some participants losing up to 28.7% at 68 weeks In real terms, if you weigh 250 pounds, that could mean losing around 52 pounds with tirzepatide compared to potentially 6072 pounds with retatrutide
It is also, critically, a determinant of resting metabolic rate, the amount of energy the body burns at rest
