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ROS-induced DNA lesions activate the p53 pathway, promoting Bax expression, mitochondrial cytochrome c release, apoptosome assembly, and caspase-9/3 activation, culminating in apoptosis (Zhou et al., 2025)

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10.1021/acs.jafc.8b06402 48 ChenS.WuX.DuanJ.HuangP.LiT.YinY.et al (2021)

These foundations become even more important with long-term use

10.3233/JAD-181123 11 AngkeowP.DeshpandeS