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Let's review a few of the more popular weight loss medications and how they compare to semaglutide

Summary: Most patients notice appetite suppression and early blood glucose improvements within 12 weeks of starting GLP-1 therapy, with measurable weight loss typically appearing after 48 weeks and maximum benefits emerging after several months on the maintenance dose

Recommended protocol: Washout: 30 to 35 days (conservative, recommended) Starting dose: 2mg weekly (resist the urge to start higher) Week 5: escalate to 4mg Week 9: escalate to 8mg Week 13: escalate to 12mg Yes, you start at 2mg despite coming from 15mg tirzepatide

Further research will be crucial in defining the optimal use, safety, and full spectrum of benefits of this combination therapy in various populations

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