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Indications: type II diabetes mellitus a supplement to sulfonylurea or insulin therapy Contraindications: type 1 diabetes patients with heart failure (see black box warning) active liver disease (or elevated transaminase levels) - due to increased risk of hepatic injury active bladder cancer The results from clinical trials have been mixed

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Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial