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For TB-500, receptor-level tachyphylaxis is unlikely because thymosin beta-4 acts largely as an extracellular signaling molecule rather than a receptor agonist
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These changes can be categorized broadly into global/repetitive element methylation, gene-specific methylation, miRNA methylation, epigenetic clock genes alterations (see above), and methylation of immune- and retroviral-related elements 204
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