Diabetes Care 48(1):S207-38 Marx N, Federici M, Schtt K, Mller-Wieland D, Ajjan RA, Antunes MJ et al (2023) 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes: developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC)
Discontinuation, regain, and reinitiation (class-level, semaglutide / tirzepatide) Budini 2026 ( eClinicalMedicine ) pooled regain curve: asymptotic maximum regain 75.3% of lost weight, half-life about 23 weeks, so roughly 60% of the loss returns by 12 months and about 40% is still held at a year
Darkened skin patches A B12 shortage can affect melanin activity, causing darker areas near the mouth or eyes
Together, they play a critical role in glucose homeostasis by stimulating insulin secretion following a meal
And patients draw it with syringes marked in units