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To investigate the importance of direct cholesterol interactions in modulating beta cell GLP-1R function, we have screened 12 residues selected from the cholesterol binding sites identified in our cgMD simulations, covering a wide range of occupancy, residence time, ability to tolerate the planned mutation, and varied locations within binding sites in active versus inactive states

Hungele and R

Keywords: Esketamine, acute lung injury, limb ischemia-reperfusion, TLR4/NF-B/NLRP3 pathway, inflammatory cytokine, oxidative stress

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They may also be used for diabetes, hypogonadism, and metabolic disorders