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About the review The present Review summarizes evidence from major randomized trials and clinical development programs in the field, drawing on literature identified through database searches including PubMed and focusing on key advances reported through October 2025

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According to our in silico predictions, the changes in metabolic fluxes in the mutant significantly impacted arginine synthesis and pathways related to NAD metabolism, indicating a redistribution toward stress protection in response to decreased glutathione content

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