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Benefits may be seen within months, especially if significant weight loss occurs

Those reported in less than 1% of tramadol study patients include abnormal dreams, abnormal gait or ataxia, abnormal thinking, amnesia, clamminess, impaired cognition or difficulty in concentration, disorientation, hyperkinesis, irritability, night sweats, pallor, sedation, sleep apnea syndrome, suicidal ideation or tendency, and twitching

The 2023 to 2024 cisplatin and carboplatin shortage followed exactly this logic: a small number of generic manufacturers had been producing the drugs on thin margins with a concentrated API supply base

Gastrointestinal symptoms typically improve over time as the body adapts to the medication, though the timeframe varies between individuals

Food and Drug Administration and European Medicines Agency, and UK SmPC hosting via the electronic Medicines Compendium (emc), plus pharmacovigilance-oriented publications using FAERS (and, where available, broader databases)