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After that, potency becomes questionable

The STEP 1 trial (Wilding et al., The Lancet, 2021) showed an average weight loss of 14.9% over 68 weeks versus 2.4% in the placebo group a landmark result that established semaglutide as the benchmark for GLP-1 weight loss

This is especially important if you take medications that may interact with semaglutide, like berberine , metformin , or bupropion

GLP-1 drugs for diabetes and weight-loss management have become a meaningful and growing component of pharmacy spend, and will continue to impact employer pharmacy costs in 2026. When employer healthcare costs rise, companies almost always shift more costs onto their workers in the form of premiums that employees pay out of their paychecks or various cost-sharing methods like co-payments or deductibles