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(Peptide Sciences) Oncology & adjunctive therapy Interestingly, since senescent cells often accumulate in tissues post-chemotherapy and may contribute to relapse or fibrosis, FOXO4-DRI might serve as adjuncts in oncology (preclinical) by clearing therapy-induced senescent cells

Loren Pickart first isolated it in 1973 while studying compounds involved in tissue repair and regeneration

Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10

Q4: Are there side effects