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The intracellular reduction of cystine to cysteine requires NADPH

Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan

However, when normalized for neuronal volume using the MRS biomarker N-acetyl aspartate (NAA), there is clear evidence for an elevation of neuronal glutamate in nine out of thirteen studies reviewed, an observation consistent with the predictions of the model of increased activity of glutamatergic neurons and excitotoxicity