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It is thought that the loss of incretin effect is from (1) a reduction in secretion of incretin hormone in response to nutrients (hyposecretion) and/or (2) a reduction in insulinotropic effect on pancreatic beta cells (insulin resistance)
Biochem Biophys Res Commun 2008
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In non-clinical laboratory research, this peptide may be applied in receptor binding assays, cell-based signaling studies, ligand interaction experiments, and controlled protocols designed to evaluate peptide behavior
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