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Indeed, humans with homozygous loss-of-function mutations in the ANGPTL3 gene have low serum levels of not only triglycerides and apo-B-containing lipoproteins (VLDL/LDL) but also low levels of apoA-I lipoproteins (HDL)
doi:10.1056/NEJMcp1816152 Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG
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