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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

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Men with low zinc levels often show reduced sperm count and motility

Therefore, the changes in the dosage form or the combination with other drugs can further compensate for the weakness of low bioavailability of berberine

However, overdoing it can lead to potential side effects and skin issues