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GLP-1 analogues can cause a condition called pancreatitis

Studies have shown that certain cytokines, such as IL-6, appear to be particularly elevated in patients with PIMS-TS and may be involved in myocardial depression.2 Studies have also suggested that life-threatening COVID-19 pneumonia may be associated with monogenic inborn errors of immunity related to type 1 interferonopathies or type 1 interferon neutralising antibodies.4 Certain human leukocyte antigens, which are prevalent in East Asians but not Caucasians, have been associated with KD.4 However, no genes have been identified to cause PIMS-TS

Am J Physiol Endocrinol Metab 305(11):E1367E1374 Dickson SL et al (2012) The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors

Instead, it selectively activates the innate repair receptor (IRR), a complex formed by the EPO receptor and the beta common receptor (CD131)