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[127] [128] Synthesis [edit] Biosynthesis [edit] Vitamin B 12 is derived from a tetrapyrrolic structural framework created by the enzymes deaminase and cosynthetase which transform aminolevulinic acid via porphobilinogen and hydroxymethylbilane to uroporphyrinogen III
However, animal studies have shown systemic effects with oral ingestion and caution is needed
Extended follow-up studies would identify any delayed adverse effects and establish whether therapeutic benefits persist, diminish, or require continued treatment for maintenance
The details and results for this trial are still pending
The peptide has a short half-life of less than 30 minutes and is rapidly metabolized, which means consistent dosing protocols matter significantly
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