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Endocrinology 153: 3054-3065, 2012
Medicare does cover GLP-1s today, but only when prescribed for an underlying condition, not just for weight loss
Weight loss tends to plateau after 1218 months, and maintaining results requires ongoing treatment combined with habit changes
How Semaglutide Works Semaglutide binds to GLP-1 receptors throughout the body, producing several coordinated effects that promote weight loss and metabolic health (3): Appetite suppression: Acts on hypothalamic appetite centers to reduce hunger and increase satiety Delayed gastric emptying: Slows the rate at which food leaves the stomach, promoting longer-lasting fullness Enhanced insulin secretion: Stimulates glucose-dependent insulin release, improving blood sugar control Reduced glucagon secretion: Lowers the hormone that raises blood sugar levels Central reward pathway modulation: May reduce food cravings and reward-driven eating behavior Semaglutide for weight loss is administered as a once-weekly subcutaneous injection with a gradual dose escalation from 0.25 mg to a target dose of 2.4 mg over 16 to 20 weeks
If bruising persists beyond one week or worsens, contact your PlexusDx providerthis may indicate repeated injection into the same site or a bleeding disorder requiring evaluation
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