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How do cells cope with RNA damage and its consequences

Dysfunction of cystinosin results in the intralysosomal accumulation of the disulfide cystine, which crystallizes in some tissues and damages many parenchymal organs

Even when caloric intake drops, the food chatter tends to spike, leading to frustration, fatigue, and rebound

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In this work, the species-specific, pH-independent standard redox potentials of glutathione were determined primarily by comparing it to 1-methylnicotinamide, the simplest NAD + analogue