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Gradual weight loss (0.51 kg weekly) through diet and exercise minimises gallstone risks whilst achieving health benefits

10.1016/j.fertnstert.2014.03.044 263 YiY.HaoZ.SunP.FanK.YinW.GuoJ.et al (2022)

For example, some limited research suggests using GLP-1s may help prevent cognitive decline and neurodegenerative conditions like dementia in certain populations

If your provider is not familiar with the combination approach, you can reference the Mayo Clinic study and the British Menopause Society guidance

Fasting itself increases: Glucagon activity Fat mobilization Ketone production In Type 1 diabetes, without adequate insulin to suppress this, ketones can rise rapidly