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These three mRNAs collectively encode the G6PD isoform a (545 amino acids) and isoform b (515 amino acids) enzymes

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GSH also regulates redox-sensitive signaling pathways, modulates inflammatory processes, and supports innate immune responsesfurther underscoring its central role in CNS neuroprotection

In this last case, transmethylation capacity is limited because the tissue distribution of the enzyme is restricted to specific organs (Delgado-Reyes et al., 2001)