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While the results were encouraging, by the mid-1990s Holst and Carolyn Deacon, a physiologist at the University of Copenhagen, confirmed an earlier finding by Rolf Mentlein, Baptist Galllwitz and Wolfgang Schmidt based at the University of Kiel in Germany who had found in 1993 that GLP-1 did not last long in the body because it was broken down in minutes by dipeptidyl peptidase-IV (DPP-4), an enzyme found in numerous tissues and in the bloodstream (Mentlein, Galllwitz, Schmidt
The combined 8mg groups in the trial lost 22.8% of body weight at 48 weeks, with 100% of participants achieving at least 5% weight loss and 91% achieving 10% or more
For example, it is used alongside peptides, antioxidants, and delivery technologies to create high-performance formulations
This approach ensures the treatment remains effective while minimizing potential side effects
Some formulations also carry indications for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
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