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The most dramatic increase is in the perimenopause population: as of February 2026, 1 in 20 women aged 4554 has an active estrogen-based HRT prescription, a 184% increase across the study period

The pathogenesis of NAFLD, schematically represented in Figure 2, is multifactorial and multiple mechanisms have been proposed to explain the process of excessive liver lipid accumulation, with the subsequent possible inflammation and fibrosis (36)

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Zhang T, Ma M, Chen T, Zhang L, Fan L, Zhang W, Wei B, Zhang D, Li S, Xuan W, Noctor G, Han Y (2020) Glutathione-dependent denitrosation of GSNOR1 promotes oxidative signalling downstream of H 2 O 2