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IGF-1 LR3 bypasses that entire regulatory sequence and acts directly on tissue-level IGF-1 receptors, which is why research describes its signaling onset as faster and more direct than secretagogue-based approaches, though also more potent at the receptor level
At position 3 on the chain Glu(E) was substituted with Arg(R), which gives the name LR3
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Renukuntla J, Vadlapudi AD, Patel A, et al
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