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However, the evidence does not support confident recommendations

Diagnosis, natural history, and management in vascular EhlersDanlos syndrome

While it has been associated with numerous negative health impacts, the kidney has been noted to be its main target organ and studies indicate its association with nephrotoxicity in humans and animals

Overall, the arginineproline metabolic axis plays a complex role in IPF, modulating both fibrotic and inflammatory processes

These findings were originally interpreted as the results of the inhibition exerted by rapamycin on the molecular complex named mammalian target of rapamycin (mTOR) (Ali et al