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In comparison, patients who used retatrutide (8 mg and 12 mg once weekly) lost 17.5% at 24 weeks and 24.2% of their body weight after 48 weeks in phase 2 clinical trials

Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs

However, its recommended that patients avoid processed and sugary foods to allow Ozempic to aid the body properly

For patients who find weekly semaglutide's prolonged nausea intolerable, this pharmacokinetic difference is clinically relevant

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