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eClinicalMedicine (Part of The Lancet Discovery Science)

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Clinically, GLP-1RAs like semaglutide induce sweet hyposensitivity and reduce preference for hyperpalatable foods, an effect mediated by changes in endogenous GLP-1 secretion and synaptic plasticity in reward circuits (166)

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Once-Weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine 384(11) 2021PMID: 33567185 NEJM 4 Jastreboff AM, Aronne LJ, Ahmad NN, et al

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