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Standard Dosing Range: Low dose: 200 to 250 mcg once daily Moderate dose: 250 to 500 mcg once or twice daily Higher dose: 500 to 800 mcg once or twice daily Weight-Based Dosing: Based on animal study extrapolations, an estimated human equivalent dose is approximately 1.6 mcg/kg body weight, translating to roughly 110 mcg for a 150-pound person and 145 mcg for a 200-pound person when using oral administration

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Moreover, the expression of key spermatogenesis markers, including UCHL1, PLZF, SCP3, and PCNA, which were reduced in aged testes, were significantly restored or increased following FOXO4-DRI treatment