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Neuroendocrine, Sexual Function, and Metabolic Studies: Investigated in preclinical and human models to assess the effects of MC4R activation on sexual behavior, appetite regulation, and energy balance through MC3R/MC4R pathways

Two 2013 systematic reviews of interventions concluded that the modest benefit of propionyl-L-carnitine on walking performance was equivalent or superior to that obtained with drugs approved for claudication in the US (e.g., pentoxyphylline, cilostazol) yet inferior to improvements seen with supervised exercise interventions (69, 70)

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