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Initial weight loss typically begins within 2-4 weeks, with more significant results after reaching maintenance dosing
The rate of weight gain after drug discontinuation was not dependent on the level of support provided during the period after medication discontinuation
Participants were matched by total body mass and then randomly assigned a supplementation protocol, in double-blind fashion, consisting of the oral ingestion of either 200 mg/day of GSH + 2 g/day of L-citrulline [GSH + CIT ( n = 25)], 2 g/day of L-citrulline-malate [CIT-malate ( n = 25)], or 2.52 g/day of cellulose placebo ( n = 25)
Additionally, the degree of appetite reduction may plateau or diminish slightly over time as physiological adaptation occurs, though clinical efficacy generally persists with continued use
M.DeubelS.Brigelius-FlohR
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