GLP-1 drugs are stronger and longer-lasting than the body's natural GLP-1 hormone, says Janelle Duah, MD, associate medical director at Maven Clinic, a virtual clinic of women's and family health, based in New Haven, Connecticut
What to set as your healthy expectation if youre starting GLP-1 If you want a clean, realistic way to frame it: First 12 months: appetite shifts + early weight movement By ~4 months: more noticeable progress (if dose escalation is tolerated) (Source: European Medicines Agency (EMA)) By ~1216 months: many eligible adults land in the 1015% weight-loss range (some higher, some lower) (Source: New England Journal of Medicine) Best outcomes happen when you protect muscle (protein + strength) and build routines you can sustain.
They become less careful about hydration
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