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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Glutathione, our bodys homegrown hero, is a champ at many things

The goal isnt to eliminate all methemoglobin, but merely to reduce the methemoglobin to a safe level (please see the discussion below regarding the functional hemoglobin level )

Dull and lacklustre skin

They were testing a range of Lactobacillus bacteria to see which provided the most antioxidant activity