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Its about finding the minimum effective dose, not the maximum tolerable one

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A Critical Review of Secondary Neurodegeneration and Amyloid-beta Accumulation after Stroke

If someone is diabetic or maybe pre-diabetic, then you may have a situation where your blood glucose goes high, and it's difficult to control." Symptoms of high blood glucose levels can include excessive thirst, frequent urination, headache and fatigue, and they can lead to dehydration, dizziness and nausea or vomiting

Gene-specific primers ( pGcg , pGLP1R and pDPP-4 sense and anti-sense primers in Supplementary Table S1) were designed based on the known coding sequences of pGcg , pGlp-1r or pDpp-4