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Conditions such as diabetes mellitus, insulin resistance, high-density lipoprotein isoform alterations, fatty acid elongation enzyme activity, and metabolic syndrome have been associated with migraine

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These effects are initially mediated by natriuresis and plasma volume contraction, but sustained effects likely reflect additional mechanisms including reduced total body sodium, decrease in intracellular sodium and calcium, and vasodilation

Research has suggested that these drugs may lower the risk of major cardiovascular events, such as heart attacks and strokes, by improving overall metabolic health