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Remarkably, however, it is still not understood why the glucagon response is deficient or even absent in individuals with type 1 diabetes (and long-standing type 2 diabetes [58]), where this deficient response appears to be independent of the presence or absence of autonomic neuropathy [59]

Overuse increases the risk of complications and long-term health issues

Injectable administration is hypothesized to provide systemic distribution, but human pharmacokinetic data for this route does not exist

Some practitioners theorize that local administration to abdominal fat may enhance regional lipolytic effects, though this has not been conclusively proven

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