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Semaglutide: An FDA-Approved Medication Semaglutide is an FDA-approved medication that works by mimicking a natural hormone, GLP-1, which regulates appetite and blood sugar levels

Evidence also suggests antidepressant effects of GLP-1RAs

The study concluded that "minor deviations from the weekly schedule do not require dose adjustment." The 48-hour window (dosing anywhere from day 5 to day 9 of your cycle) keeps you within that 15% variation threshold

Multiple injection sites are available, and using a consistent rotation pattern gives each area time to recover between injections

It's available only in a 60-count bottle, costs a bit more ($23.50-$26.25), and has a different formulation (750mg of milk thistle extract with no phospholipids and no Siliphos)