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Rotate the injection site with each dose to avoid local tissue buildup

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Cecal samples Cecal weight was measured since the weight of this portion of the intestine appears to be highly influenced by the microbiome (e.g., certain antibiotic treatments dramatically increase cecal weight 27,28,29,30,31 but not the colon 27 )

This multi-pathway approach reflects current understanding that optimal tissue regeneration requires orchestration of diverse biological processes rather than amplification of any single pathway