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This broad tissue distribution explains why GLP-1 RAs exert effects on multiple organ systems simultaneously, a property that makes them particularly suited to address the complex pathophysiology of NASH, which involves dysregulation of glucose and lipid metabolism, insulin resistance, inflammation, and fibrosis

Key biomarkers include glutathione levels, malondialdehyde (MDA), 8-isoprostane, and C-reactive protein to establish baseline oxidative burden

In some cases, patients may use one class of medication

This can lead to side effects like sudden blood sugar spikes, increased hunger, and quick weight regain, potentially undoing much of the progress achieved during treatment

It is sometimes used off-label for purported anti-aging purposes, body composition improvement, and metabolic enhancement, though it lacks FDA approval for these indications