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specifically, the fleeting existence of radical species and the rapid rate at which redox cycling can generate ROS, causing oxidative stress 5,7,28

This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, which is mediated by the induction and maintenance of autophagy and mitophagy, but also on their potential clinical relevance

doi: 10.1080/17425255.2019.1588884 59 FussellKCUdasinRGSmithPJGalloMALaskinJD

Decker SRR et al

This 24-week clinical trial demonstrated that supplementation with Glutathione precursors (GlyNAC) in 8 generally healthy individuals boosts GSH levels and improves oxidative stress, mitochondrial function, inflammation, physical and cognitive function