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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

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MT-II and PT-141 are baseline-resolved with typical retention time difference of 2-4 minutes

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While mild dry mouth is generally manageable with self-care measures, certain circumstances warrant prompt medical evaluation to rule out more serious underlying conditions or complications