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Description

AMPK phosphorylates NRF2 at the Ser550 residue located in the canonical NES sequence, facilitating NRF2 nuclear accumulation, probably by inhibiting nuclear export [212], and this effect is enhanced by GSK-3 inhibition [213]

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described the correlation between serum and CSF UA levels in patients with AD regarding BBB integrity and AD progression [195]

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For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit

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